Second in a row: another collaborative article, this time at Org. Lett., is now available on-line

11/10/2023

We are really glad to announce here that another collaborative article accepted at Org. Lett., entitled "Cobalt(I)-Catalyzed (3 + 2 + 2) Cycloaddition between Alkylidenecyclopropanes, Alkynes, and Alkenes" and authored by E. da Concepción, C. Lázaro, I. Fernández, J. L. Mascareñas and F. López, is already available through the journal website.

Abstract: Cobalt(I) catalysts equipped with bisphosphine ligands can be used to promote formal (3 + 2 + 2) intramolecular cycloadditions of enynylidenecyclopropanes of type 1. The method provides synthetically appealing 5,7,5-fused tricyclic systems in good yields and with complete diastereo- and chemoselectivity. Interestingly, its scope differs from that of previously reported annulations based on precious metal catalysts, specifically rhodium and palladium. Noticeably, density functional theory calculations confirm that the mechanism of the reaction is also different from those proposed for these other catalysts.


External link: https://pubs.acs.org/doi/10.1021/acs.orglett.3c03511