Congrats to Borja, on his successful PhD defense
06/10/2022External link: https://twitter.com/ciqususc/status/1535246221882834948
Please find below all relevant news regarding our Group.
Click on a headline in order to read the full article.
External link: https://twitter.com/ciqususc/status/1535246221882834948
External link: https://www.usc.es/ciqus/en/news/ciqus-phd-student-daniel-marcos-wins-one-seven-national-fulbright-grants-stays-abroad
External link: https://iupac.org/winners-of-the-2022-iupac-solvay-international-award-for-young-chemists/
Abstract: Translating the power of transition metal catalysis to the native habitats of enzymes can significantly expand the possibilities of interrogating or manipulating natural biological systems, including living cells and organisms. This is especially relevant for organometallic reactions that have shown great potential in the field of organic synthesis, like the metalcatalyzed transfer of carbenes. While, at first sight, performing metal carbene chemistry in aqueous solvents, and especially in biologically relevant mixtures, does not seem obvious, in recent years there have been a growing number of reports demonstrating the feasibility of the task. Either using small molecule metal catalysts or artificial metalloenzymes, a number of carbene transfer reactions that tolerate aqueous and biorelevant media are being developed. This review intends to summarize the most relevant contributions, and establish the state of the art in this emerging research field.
External link: https://pubs.rsc.org/en/content/articlelanding/2022/sc/d2sc00721e
Abstract: The possibility of performing designed transition-metal catalyzed reactions in biological and living contexts can open unprecedented opportunities to interrogate and interfere with biology. However, the task is far from obvious, in part because of the presumed incompatibly between organometallic chemistry and complex aqueous environments. Nonetheless, in the past decade there has been a steady progress in this research area, and several transition-metal (TM)-catalyzed bioorthogonal and biocompatible reactions have been developed. These reactions encompass a wide range of mechanistic profiles, which are very different from those used by natural metalloenzymes. Herein we present a summary of the latest progress in the field of TM-catalyzed bioorthogonal reactions, with a special focus on those triggered by activation of multiple carbon-carbon bonds.
External link: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202200118
External link: https://twitter.com/ciqususc/status/1517513552982122496
Abstract: Pd(0) catalysts featuring phosphorous-based monodentate ligands can detour the reactivity of carbonyl-tethered alkylidenecyclopropanes (ACPs) from standard (3+2) cycloadditions towards tandem cycloisomerization / cross-coupling processes. This new reactivity lies on the formation of key π-allyl oxapalladacyclic intermediates, which are subsequently trapped with external nucleophilic partners, instead of undergoing canonical C-O reductive eliminations. Importantly, the use of imine-tethered ACP’s is also feasible. Therefore, the method provides a straightforward and stereoselective entry to a wide variety of highly functionalized cyclic alcohols and amines.
External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202202295
We are really pleased to announce here that our research article at RSC Adv., entitled "Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage" and authored by J. Rodríguez, C. Pérez-González, M. Martínez-Calvo, J. Mosquera and J. L. Mascarenas has been accepted and it's already on-line (gold Open Access).
Abstract: Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of palladium reagents that trigger the cleavage of the spacer, and the release of unfunctional monomeric peptides.
External link: https://pubs.rsc.org/en/content/articlelanding/2022/ra/d1ra09180h
External link: https://pubs.acs.org/doi/10.1021/acsnano.1c07983
External link: https://twitter.com/MetBioCat/status/1448690500110888960