Please find below all relevant news regarding our Group.
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External link: https://barluengalecture.org/
So glad to announce our last collaborative work (with Javier Montenegro group, CiQUS) was selected as the front cover of the last Chem. Sci. published issue.
External link: https://www.usc.es/ciqus/es/noticias/jointchemicalscience
External link: https://www.usc.es/ciqus/es/noticias/medallajlmasca
Abstract: We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)2b4bpy]2+, Δ‑4Ru) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.
So pleased to share we have our last paper at Organic Process Research & Development accepted. It is entitled "Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions" and authored by Prof. Moisés Gulías, Daniel Marcos-Atanes, Prof. José L. Mascareñas and Dr. Marc Font
Abstract: Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadings.
External link: https://pubs.acs.org/doi/10.1021/acs.oprd.9b00191