Pleased to announce our Chem. Sci. manuscript in colaboration with Montenegro group (CiQUS) has been accepted, and it's already on-line
We are so glad to annouce our communication to Chem. Sci. in collaboration with our CiQUS colleagues at J. Montenegro's lab, entitled "Supramolecular Caging for Cytosolic Delivery of Anionic Probes" and authored by H. Fernández-Caro, I. Lostalé-Seijo, M. Martinez-Calvo, J. Mosquera, J. L. Mascareñas and J. Montenegro, has been accepted and it's already available through the journal website.
Abstract: The cytosolic delivery of hydrophilic, anionic molecular probes and
therapeutics is a major challenge in chemical biology and medicine.
Herein, we describe the design and synthesis of peptide-cage hybrids
that allow an efficient supramolecular binding, cell membrane
translocation and cytosolic delivery of a number of anionic dyes,
including pyranine, carboxyfluorescein and several sulfonate-containing
Alexa dyes. This supramolecular caging strategy is successful in
different cell lines, and the dynamic carrier mechanism has been
validated by U-Tube experiments. The high efficiency of the reported
approach allowed intracellular pH tracking by exploiting the ratiometric
excitation of the pyranine fluorescent probe
External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/SC/C9SC02906K#!divAbstract
