Please find below all relevant news regarding our Group.
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Our last publication at the Chem. Sci. journal is on-line

Pleased to announce our Chem. Sci. manuscript in colaboration with Montenegro group (CiQUS) has been accepted, and it's already on-line

We are so glad to annouce our communication to Chem. Sci. in collaboration with our CiQUS colleagues at J. Montenegro's lab, entitled "Supramolecular Caging for Cytosolic Delivery of Anionic Probes" and authored by H. Fernández-Caro, I. Lostalé-Seijo, M. Martinez-Calvo, J. Mosquera, J. L. Mascareñas and J. Montenegro, has been accepted and it's already available through the journal website.

Abstract: The cytosolic delivery of hydrophilic, anionic molecular probes and therapeutics is a major challenge in chemical biology and medicine. Herein, we describe the design and synthesis of peptide-cage hybrids that allow an efficient supramolecular binding, cell membrane translocation and cytosolic delivery of a number of anionic dyes, including pyranine, carboxyfluorescein and several sulfonate-containing Alexa dyes. This supramolecular caging strategy is successful in different cell lines, and the dynamic carrier mechanism has been validated by U-Tube experiments. The high efficiency of the reported approach allowed intracellular pH tracking by exploiting the ratiometric excitation of the pyranine fluorescent probe

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Already available our last publication at Chem. Sci.

We are very pleased to announce our latest collaboration with Prof. M. E. Vázquez, Dr. M. Melle-Franco and Prof. M. Vázquez has been published

Glad to announce our most recent publication at the Chem. Sci. journal, entitled "Canonical DNA minor groove insertion of bisbenzamidine-Ru(II) complexes with chiral selectivity" and authored by M.I. Sanchez, G. Rama, R. Calo-Lapido, K. Ucar, P. Lincoln, M. Vázquez, M. Melle-Franco, J. L. Mascareñas  and M. E. Vázquez, is already available.

Abstract: We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)2b4bpy]2+, Δ‑4Ru) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

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Our last publication at Org. Process Res. Dev., part of the "Special Issue Honoring 25 Years of the Buchwald-Hartwig Amination", is available on-line

Happy to announce our Organic Process Research & Development brand new manuscript it's already on-line

So pleased to share we have our last paper at Organic Process Research & Development accepted. It is entitled "Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions" and authored by Prof. Moisés Gulías, Daniel Marcos-Atanes, Prof. José L. Mascareñas and Dr. Marc Font

Abstract: Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadings.

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The new Master's degree in 'Chemistry at the Interface with Biology and Materials Science', starting next academic year, has opened its admission period

The enrolment period will be open until July 19th, and there will be a maximum of 20 new students

The USC (University of Santiago de Compostela) offers this new international master's program with an interdisciplinary profile, linked to the CiQUS strategic research areas.
This is the first official master's degree in Spain for graduate students who wish to deepen knowledge in science at the boundaries between chemistry, biology and nanomaterials.

That ambitious academic initiative will begin its activity in September 2019.
See further info at:

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Our last publication at ChemBioChem is available on-line

Pleased to announce our ChemBioChem manuscript has been accepted, and it's already on-line

So happy to share we have our last review at ChemBioChem accepted. It is entitled "TiO2‐based Photocatalysis at the Interface with Biology and Biomedicine" and authored by Dr. María Tomás Gamasa and Prof. José L. Mascareñas.

Abstract: The conversion of sunlight into chemical energy using the photosynthetic machinery is at the hearth of Nature and Life. Scientists have also learned to use the energy of light to promote a great variety of chemical reactions, most of them based on redox processes involving electron transfer steps. Indeed, the area of photoredox catalysis has recently emerged as one of the hottest fields in synthetic chemistry. Many of the photoredox reactions so far discovered take place in homogeneous phases, and rely on the use of soluble photoresponsive catalysts. However, along recent years, there have been also many advances in the area of heterogeneous photocatalysis, most of which are based on the use of semiconductor materials like TiO2 as key photocatalytic system. These technologies have found different applications, especially in the field of sustainable chemistry and therapy. In this manuscript we review some of these applications, and the potential of TiO2‐based photocatalysts in biology and biomedicine.

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