News

Please find below all relevant news regarding our Group.
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Our last publication at the Org. Biomol. Chem. journal is on-line

05/30/2019
So glad to announce our Org. Biomol. Chem. manuscript is already available on-line as Accepted Manuscript

We are so pleased to annouce our communication to Organic & Biomolecular Chemistry, entitled "A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC" and authored by R. Calo, C. Penas, A. Jiménez-Balsa, E. Vázquez and J. L. Mascareñas, has been accepted and it's already available through the journal website.

Abstract: We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both routes allowed the efficient synthesis of a miniprotein which is capable of heterodimerizing with MAX, and replicate the DNA binding of the native protein. The versatility of the reported synthetic approach enabled the straightforward preparation of MYC and Omomyc analogues, as well as fluorescently labeled derivatives


External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/OB/C9OB01209E#!divAbstract

Already available our first publication at ACS Omega

04/05/2019
We are very pleased to announce our latest manuscript has been published at ACS Omega

Glad to announce our most recent publication at the ACS Omega journal, entitled "Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkyness" and authored by D. F. Fernández, N. Casanova, J. L. Mascareñas and M. Gulías, is already available.

Abstract:
Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumarin derivatives in moderate to good yields. The α-pyrone moiety of the products provides for further manipulations to obtain relatively complex cyclic skeletons in a very simple manner.


External link: https://pubs.acs.org/doi/10.1021/acsomega.9b00022

Our recent publication in ACS Accounts of Chemical Research, among the top 3 most downloaded papers in the month of January

02/05/2019
So glad to announce our Acc. Chem. Res. manuscript is available as Article ASAP, and also getting an amazing acknowledgement and lots of attention

We are so pleased to annouce our publication at Account of Chemical Research is one of the top 3 most downloaded papers in January.
It is entitled "Allenes and Derivatives in Gold(I)- and Platinum(II)-Catalyzed Formal Cycloadditions" and authored by J. L. Mascareñas, I. Varela and F. López.

In this Account, we present recent efforts on the development of platinum- and gold-catalyzed formal cycloadditions of allenes, only including annulations initiated by a direct metal-promoted activation of the allene moiety.This Account is organized considering the number of atoms engaged in the annulation process, and when possible, we present the results in a chronological order.







External link: https://pubs.acs.org/doi/10.1021/acs.accounts.8b00567

Already on-line our first publication for 2019

01/13/2019
We are very pleased to announce our latest publication at J. Am. Chem. Soc. is already available

Glad to announce our most recent publication at the Journal of the American Chemical Society in this brand new 2019 year, entitled "Palladium-catalyzed, enantioselective formal cycloaddition between benzyltriflamides and allenes: Straightforward access to enantioen-riched isoquinolines" and authored by X. Vidal, J. L. Mascareñas and M. Gulías, is already available as just accepted manuscript.

Abstract:
Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when carried out in presence of designed N-protected amino acids as metal ligands. More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing, annulative C-H activations of prochiral diarylmethylphenyl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios.

External link: https://pubs.acs.org/doi/10.1021/jacs.8b12636