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News

Please find below all relevant news regarding our Group.
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Already available our first publication at ACS Omega

04/05/2019
We are very pleased to announce our latest manuscript has been published at ACS Omega

Glad to announce our most recent publication at the ACS Omega journal, entitled "Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkyness" and authored by D. F. Fernadez, N. Casanova, J. L. Mascareñas and M. Gulías, is already available.

Abstract:
Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumarin derivatives in moderate to good yields. The α-pyrone moiety of the products provides for further manipulations to obtain relatively complex cyclic skeletons in a very simple manner.


External link: https://pubs.acs.org/doi/10.1021/acsomega.9b00022

Our last publication at the J. Am. Chem. Soc. is on-line

03/20/2019
This recent article at the Journal of the American Chemical Society is already available as a just accepted manuscript

We are very glad to announce the publication of our latest paper at the Journal of the American Chemical Society, entitled "Ruthenium-catalyzed Redox Isomerizations inside Living Cells", by C. Vidal, M. Tomás-Gamasa, A. Gutiérrez González and J. L. Mascareñas.
We have reported how tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the “in cellulo” generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to fur-ther demonstrate the compatibility of organometallic mechanisms with the complex environment of cells.


External link: https://www.usc.es/ciqus/en/noticias/catalizadores-rutenio-jacs

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Our last publication at Chem. Sci. highlighted as 'Pick of the Week' is also selected for the 2019 Chem Sci HOT Article Collection

03/06/2019
This article is part of the themed collections: '2019 Chemical Science HOT Article Collection' and '2019 ChemSci Pick of the Week Collection'

We are really pleased to announce our last paper in the Chemical Science journal has been selected by the Editorial Team as 'Pick of the Week' on the 23rd of January, and is part of the 2019 HOT article collection.

The publication, entitled "Hollow Nanoreactors for Pd-catalyzed Suzuki- Miyaura Couplings and O-Propargyl Cleavage Reactions in Bio-relevant Aqueous Media" by P. Destito, A. Sousa-Castillo, J. R. Couceiro, F. López, M. Angel Correa-Duarte and J. L. Mascareñas, describes the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles, and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki-Miyaura cross-couplings, in water, and under physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in presence of relatively high concentrations of biomolecular components, and even in the presence of mammalian cells.


Link to the manuscript: https://t.co/K8Eh0uBpN6









External link: http://www.rsc.org/news-events/journals-highlights/2019/jan/microscopic-chemistry-labs/

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Congrats Paolo, and good luck in your new position

02/27/2019
Paolo Destito has defended his PhD Thesis today, February the 27th

Paolo Destito has defended today his PhD Thesis, entitled "Transition-metal promoted bioorthogonal transformations in biological media" and supervised by Prof. Mascareñas and Dr. López.

It was a really successful defense at the Faculty of Chemistry (USC), getting the maximum qualification from the PhD committee.

Many congrats to you, Paolo!!


By the way, plenty of success in your new position too. Best of luck!!


External link: https://www.usc.es/ciqus/en/noticias/la-tesis-del-ciqus-paolo-destito

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Our recent publication in ACS Accounts of Chemical Research, among the top 3 most downloaded papers in the month of January

02/05/2019
So glad to announce our Acc. Chem. Res. manuscript is available as Article ASAP, and also getting an amazing acknowledgement and lots of attention

We are so pleased to annouce our publication at Account of Chemical Research is one of the top 3 most downloaded papers in January.
It is entitled "Allenes and Derivatives in Gold(I)- and Platinum(II)-Catalyzed Formal Cycloadditions" and authored by J. L. Mascareñas, I. Varela and F. López.

In this Account, we present recent efforts on the development of platinum- and gold-catalyzed formal cycloadditions of allenes, only including annulations initiated by a direct metal-promoted activation of the allene moiety.This Account is organized considering the number of atoms engaged in the annulation process, and when possible, we present the results in a chronological order.







External link: https://pubs.acs.org/doi/10.1021/acs.accounts.8b00567

Already on-line our first publication for 2019

01/13/2019
We are very pleased to announce our latest publication at J. Am. Chem. Soc. is already available

Glad to announce our most recent publication at the Journal of the American Chemical Society in this brand new 2019 year, entitled "Palladium-catalyzed, enantioselective formal cycloaddition between benzyltriflamides and allenes: Straightforward access to enantioen-riched isoquinolines" and authored by X. Vidal, J. L. Mascareñas and M. Gulías, is already available as just accepted manuscript.

Abstract:
Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when carried out in presence of designed N-protected amino acids as metal ligands. More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing, annulative C-H activations of prochiral diarylmethylphenyl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios.

External link: https://pubs.acs.org/doi/10.1021/jacs.8b12636

Congrats to Daniel and Ricardo for their accesit to "BSc in chemistry prize" 2018, 2nd edition

12/14/2018
Happy to announce Daniel M. and Ricardo R., MSc students in our research group, received today the two accesit to prize for their academic record

We are really pleased to announce our MSc students, Daniel Marcos and Ricardo Rodiño, have received today the two accesit to "BSc in chemistry Prize" recognizing their excelent academic record.

During the ceremony, we also have a former PhD student from our research group, Dr. Alejandro Delgado, giving a talk about his personnal experience and profesional career.
It's been a pleasure to have you back at the Faculty of Chemistry, Alex!!


Congrats to Daniel and Ricardo!!

External link: http://www.bioga.org/nacen-los-premios-chemists-for-our-future-para-potenciar-el-talento-y-la-iniciativa-entre-los-universitarios-gallegos-de-quimica/?lang=es

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Our last publication at the J. Am. Chem. Soc. is on-line

12/09/2018
This recent article at the Journal of the American Chemical Society is already available through the journal website

We are very glad to announce the publication of our latest paper at the Journal of the American Chemical Society, entitled "Gold(I)–catalyzed enantioselective annulations between allenes and alkene-tethered oxime ethers: A straight entry to highly substituted piperidines and aza-bridged medium-sized carbocycles", by D. C. Marcote, I. Varela, J. Fernandez-Casado, J. L. Mascareñas and F. López.
We have reported a gold-catalyzed annulation strategy that allows a straightforward assembly of piperidines and piperidine-containing aza-bridged products from readily available alkene-tethered oxime ethers (or esters) and N-allenamides.

External link: https://pubs.acs.org/doi/10.1021/jacs.8b10388

Already available on-line our last publication in Angew. Chem. Int. Ed.

12/03/2018
The manuscript "Rhodium‐catalyzed annulation of ortho‐alkenylanilides with alkynes" has been recently accepted in the prestigious journal Angewandte

The article "Rhodium‐catalyzed annulation of ortho‐alkenylanilides with alkynes: Formation of unexpected naphthalene adducts" by A. Seoane, C. Comanescu, N. Casanova, R. García-Fandiño, D. Xabier, J. L. Mascareñas and M. Gulías is already on-line as an accepted article.

Abstract: o‐Alkenyl‐N‐triflylanilides undergo Rh(III)‐catalyzed oxidative annulations with alkynes to produce different types of naphthylamides, in a process which involves the cleavage of two C‐H bonds. Remarkably, in addition to formal dehydrogenative (4C+2C) cycloadducts, the reaction also produces variable amounts of isomeric naphthylamides whose formation requires a formal migration of the alkenyl moiety from the ortho to the meta position of the anilide. Also interestingly, the annulation reaction can be efficiently carried out in the absence of external oxidants, such as Cu(OAc)2.




External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.201811747