MetBioCat
ERC Advanced Grant Project

News

Please find below all relevant news regarding our Group.
Click on a headline in order to read the full article.

Congrats to Javier, who has received the GEQO-Young scientist Award 2018

09/10/2018
We are really happy to announce our former Post-doc researcher Javier Francos has been awarded for his early career as a young scientist.

We are so pleased to communicate Javier Francos (Oviedo, 1983) has recently received one of the most important prizes for young scientists on their early careers at Spain: the Young Scientist Award, by the RSEQ-GEQO (Organometallic Chemistry specialized group, Spanish Royal Society of Chemistry).

Javier is a former Post-doc researcher at our group, and he is currently working at the University of Oviedo as a collaborating professor.

Congrats Javier!!!!




External link: http://geqo.es/geqo-awards-2018/

Highlighted at Synfacts our last publication at ACIE

08/23/2018
Happy to announce our paper Angew. Chem. Int. Ed., 2018, 57 (27), 8255-8259 has been highlighted at Synfacts

We are really happy to announce the paper entitled "Rhodium(III)‐Catalyzed Annulation of 2‐Alkenylanilides with Alkynes via C‐H Activation: a Direct Access to 2‐substituted Indolines" has been selected at Synfacts 2018; 14(09): 0915.
This work by M. Font, B. Cendón, A. Seoane, J. L. Mascareñas and M. Gulías reports the methodology for a new, mild, and selective oxidative annulation of readily available substrates in the presence of a rhodium(III) catalyst


External link: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610565

One of our latest publications highlighted at Synfacts

08/22/2018
We are really pleased to announce the ACS Catalysis, 2018, 8, 6100–6105 by F. Verdugo at al. has been highlighted at Synfacts 2018; 14(08): 0820

The publication entitled "Enantioselective Palladium-Catalyzed [3C + 2C] and [4C + 3C] Intramolecular Cycloadditions of Alkylidenecyclopropanes", by F. Verdugo, L. Villarino, J. Durán, M. Gulías, J. L. Mascareñas and F. López has been selected by Synfacts as a highlighted paper at the recently published Synfacts 2018; 14(08): 0820

Congrats guys!!

External link: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610497

Further news about the ACS Catalysis, 2018, 8 (7), pp 6055–6061

08/01/2018
Our recent paper at ACS Catalysis among the most read publications over the last month

We are very pleased to announce some good news regarding our publication at ACS Catalysis "Intracellular Deprotection Reactions Mediated by Palladium Complexes Equipped with Designed Phosphine Ligands".
The paper authored by M. Martínez-Calvo, J. R. Couceiro, P. Destito, J. Rodríguez, J. Mosquera, and J. L. Mascareñas is one of the most read articles for the previous 30 days (top 20 most downloaded).
It is an ACS Editors' Choice, too!

Thank you, guys

External link: https://pubs.acs.org/action/showMostReadArticles?journalCode=accacs#

ACS Catalysis. Third over the last 40 days... good job guys!!

07/10/2018
We are very glad to announce we got our third consecutive publication accepted at ACS Catalysis, in just fourty days.

Already available on-line our last publication at ACS catalysis by D. F. Fernández, C. A. B. Rodrigues, M. Calvelo, M. Gulías, J. L. Mascareñas and F. López, entitled "Iridium(I)-Catalyzed Intramolecular Cycloisomerization of Enynes: Scope and Mechanistic Course"

Abstract:
We report an Ir(I)-catalyzed cycloisomerization methodology that provides access to carbocyclic systems bearing exo-alkene moieties from alkynyl-equipped acyclic precursors. The method relies on the C-H activation of olefinic and (het-ero)aromatic C(sp2)–H bonds, followed by an exo-cyclization to a tethered alkyne, and provides interesting cyclic diene products that are amenable of further elaboration. Importantly, DFT calculations suggests that, in contrast to related hydrocarbonations of alkenes in which either migratory insertions or C-C reductive eliminations have been suggested to be rate determining, in our reac-tions, the energetic barrier of these steps is lower than that of the previous C–H activation.

External link: https://pubs.acs.org/doi/abs/10.1021%2Facscatal.8b02139

Our last publication at ACS Catalysis among the ACS editor’s choice articles

06/16/2018
Our latest letter to ACS Catalysis selected from acrossall ACS journals by ACS editors for its potential broad public interest

"Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands", authored by M. Martínez-Calvo, J. R. Couceiro, P. Destito, J. Rodriguez, J. Mosquera and J. L. Mascareñas, is our latest paper at ACS Catalysis.

Abstract:
Discrete palladium (II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. The performance of these complexes is superior to that of other palladium sources, which apparently are rapidly deactivated in such hostile complex media. This good balance between reactiv-ity and stability allows the use of these discrete phosphine palladium complexes in living mammalian cells, whereby they can mediate similar transformations. The presence of a phosphine ligand in the coordination sphere of palladi-um also provides for the introduction of targeting groups, such as hydrophobic phosphonium moieties, which facili-tate the accumulation of the complexes in mitochondria.



External link: https://pubs.acs.org/doi/10.1021/acscatal.8b01606

Congrats to María, who got the best oral communication award at the XI ISOMC "Marcial Morena Mañas", held in Oviedo

06/08/2018
Our colleague Dr. María Tomas-Gamasa has received the best oral communication prize at the XI international school in organometallic chemistry

Our group member Dr. María Tomás-Gamasa was awarded in Oviedo with the best oral communication prize at the XI International School on Organometallic Chemistry "Marcial Moreno Mañas", 6th-8th of June 2018.

The title of her communication was: "Ruthenium promoted reactions inside living cells", and she described the first examples of [2+2+2] cycloaddition reactions involving two exogenous, freely spreading substrates promoted by discrete ruthenium complexes inside living cells.


Another publication by the group in ACS Catalysis

06/07/2018
Already available in ASAP our last letter to ACS Catalysis

"Enantioselective Palladium-Catalyzed [3C + 2C] and [4C + 3C] Intramolecular Cycloadditions of Alkylidenecyclopropanes" by F. Verdugo, L. Villarino, J. Durán, M. Gulías, J. L. Mascareñas and F. López is already available on-line

ABSTRACT: We report a highly enantioselective [3C + 2C] intramolecular cycloaddition of alkylidenecyclopropanes (ACPs) and alkenes. The best results are obtained by using sterically demanding chiral phosphoramidite ligands derived from Vapol. Moreover, we also show that related, but less bulky, phosphoramidites can also lead to very effective [4C + 3C] cycloadditions when dienes, instead of alkenes, are used as reacting partners. The reactions provide a practical, simple, and selective access to optically active, synthetically appealing 5,5- and 5,7-bicyclic systems.


External link: https://pubs.acs.org/doi/10.1021/acscatal.8b01296

Latest publication in Nature Communication

05/15/2018
Our recent article at Nat. Commun. is already available on-line

We are very glad to announce the publication of our latest paper at Nature Communication, entitled "Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells", by C. Vidal, M. Tomás-Gamasa, P. Destito, F. López and J. L. Mascareñas.
In which, we report a gold-mediated C–C bond formation that occurs in complex aqueous habitats, and demonstrate that the reaction can be translated to living mammalian cells.

See more at: https://www.usc.es/ciqus/es/noticias/alquimistasmediocelular


External link: https://www.nature.com/articles/s41467-018-04314-5

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Just accepted our last paper in Angew. Chem. Int. Ed.

05/08/2018
Our latest communication in ACIE is ready for publishing

"Rhodium(III)‐Catalyzed Annulation of 2‐Alkenylanilides with Alkynes via C‐H Activation: a Direct Access to 2‐substituted Indolines" by Font, M., Cendón, B., Seoane, A., Mascareñas, J.L., and Gulías, M., is our recent communication to Angewandte Chemie International Edition

Abstract:
A Rh(III) complex featuring an electron‐deficient η5‐cyclopentadienyl ligand catalyzes an unusual annulation between alkynes and 2‐alkenylanilides, to form synthetically appealing 2‐substituted indolines. Formally, the process can be viewed as an allylic amination with concomitant hydrocarbonation of the alkyne. Mechanistic experiments indicate that this transformation involves a peculiar Rhodium migration with a concomitant 1,5‐H shift.

External link: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201802830