News

Please find below all relevant news regarding our Group.
Click on a headline in order to read the full article.

Already available our first publication at ACS Omega

04/05/2019
We are very pleased to announce our latest manuscript has been published at ACS Omega

Glad to announce our most recent publication at the ACS Omega journal, entitled "Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkyness" and authored by D. F. Fernadez, N. Casanova, J. L. Mascareñas and M. Gulías, is already available.

Abstract:
Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumarin derivatives in moderate to good yields. The α-pyrone moiety of the products provides for further manipulations to obtain relatively complex cyclic skeletons in a very simple manner.


External link: https://pubs.acs.org/doi/10.1021/acsomega.9b00022

Our recent publication in ACS Accounts of Chemical Research, among the top 3 most downloaded papers in the month of January

02/05/2019
So glad to announce our Acc. Chem. Res. manuscript is available as Article ASAP, and also getting an amazing acknowledgement and lots of attention

We are so pleased to annouce our publication at Account of Chemical Research is one of the top 3 most downloaded papers in January.
It is entitled "Allenes and Derivatives in Gold(I)- and Platinum(II)-Catalyzed Formal Cycloadditions" and authored by J. L. Mascareñas, I. Varela and F. López.

In this Account, we present recent efforts on the development of platinum- and gold-catalyzed formal cycloadditions of allenes, only including annulations initiated by a direct metal-promoted activation of the allene moiety.This Account is organized considering the number of atoms engaged in the annulation process, and when possible, we present the results in a chronological order.







External link: https://pubs.acs.org/doi/10.1021/acs.accounts.8b00567

Already on-line our first publication for 2019

01/13/2019
We are very pleased to announce our latest publication at J. Am. Chem. Soc. is already available

Glad to announce our most recent publication at the Journal of the American Chemical Society in this brand new 2019 year, entitled "Palladium-catalyzed, enantioselective formal cycloaddition between benzyltriflamides and allenes: Straightforward access to enantioen-riched isoquinolines" and authored by X. Vidal, J. L. Mascareñas and M. Gulías, is already available as just accepted manuscript.

Abstract:
Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when carried out in presence of designed N-protected amino acids as metal ligands. More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing, annulative C-H activations of prochiral diarylmethylphenyl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios.

External link: https://pubs.acs.org/doi/10.1021/jacs.8b12636

Our last publication at the J. Am. Chem. Soc. is on-line

12/09/2018
This recent article at the Journal of the American Chemical Society is already available through the journal website

We are very glad to announce the publication of our latest paper at the Journal of the American Chemical Society, entitled "Gold(I)–catalyzed enantioselective annulations between allenes and alkene-tethered oxime ethers: A straight entry to highly substituted piperidines and aza-bridged medium-sized carbocycles", by D. C. Marcote, I. Varela, J. Fernandez-Casado, J. L. Mascareñas and F. López.
We have reported a gold-catalyzed annulation strategy that allows a straightforward assembly of piperidines and piperidine-containing aza-bridged products from readily available alkene-tethered oxime ethers (or esters) and N-allenamides.

External link: https://pubs.acs.org/doi/10.1021/jacs.8b10388

Already available on-line our last publication in Angew. Chem. Int. Ed.

12/03/2018
The manuscript "Rhodium‐catalyzed annulation of ortho‐alkenylanilides with alkynes" has been recently accepted in the prestigious journal Angewandte

The article "Rhodium‐catalyzed annulation of ortho‐alkenylanilides with alkynes: Formation of unexpected naphthalene adducts" by A. Seoane, C. Comanescu, N. Casanova, R. García-Fandiño, D. Xabier, J. L. Mascareñas and M. Gulías is already on-line as an accepted article.

Abstract: o‐Alkenyl‐N‐triflylanilides undergo Rh(III)‐catalyzed oxidative annulations with alkynes to produce different types of naphthylamides, in a process which involves the cleavage of two C‐H bonds. Remarkably, in addition to formal dehydrogenative (4C+2C) cycloadducts, the reaction also produces variable amounts of isomeric naphthylamides whose formation requires a formal migration of the alkenyl moiety from the ortho to the meta position of the anilide. Also interestingly, the annulation reaction can be efficiently carried out in the absence of external oxidants, such as Cu(OAc)2.




External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.201811747