Please find below all relevant news regarding our Group.
Click on a headline in order to read the full article.
External link: https://www.cidadedacultura.gal/es/evento/ii-feira-da-innovacion
External link: https://barluengalecture.org/
So glad to announce our last collaborative work (with Javier Montenegro group, CiQUS) was selected as the front cover of the last Chem. Sci. published issue.
External link: https://www.usc.es/ciqus/es/noticias/jointchemicalscience
External link: https://www.usc.es/ciqus/es/noticias/medallajlmasca
We are so glad to annouce our communication to Chem. Sci. in collaboration with our CiQUS colleagues at J. Montenegro's lab, entitled "Supramolecular Caging for Cytosolic Delivery of Anionic Probes" and authored by H. Fernández-Caro, I. Lostalé-Seijo, M. Martinez-Calvo, J. Mosquera, J. L. Mascareñas and J. Montenegro, has been accepted and it's already available through the journal website. Abstract: The cytosolic delivery of hydrophilic, anionic molecular probes and
therapeutics is a major challenge in chemical biology and medicine.
Herein, we describe the design and synthesis of peptide-cage hybrids
that allow an efficient supramolecular binding, cell membrane
translocation and cytosolic delivery of a number of anionic dyes,
including pyranine, carboxyfluorescein and several sulfonate-containing
Alexa dyes. This supramolecular caging strategy is successful in
different cell lines, and the dynamic carrier mechanism has been
validated by U-Tube experiments. The high efficiency of the reported
approach allowed intracellular pH tracking by exploiting the ratiometric
excitation of the pyranine fluorescent probe
External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/SC/C9SC02906K#!divAbstract
Abstract: We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)2b4bpy]2+, Δ‑4Ru) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.
External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/SC/C9SC03053K#!divAbstract
So pleased to share we have our last paper at Organic Process Research & Development accepted. It is entitled "Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions" and authored by Prof. Moisés Gulías, Daniel Marcos-Atanes, Prof. José L. Mascareñas and Dr. Marc Font
Abstract: Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadings.
External link: https://pubs.acs.org/doi/10.1021/acs.oprd.9b00191
Iván Varela Sandá has defended today his PhD Thesis, entitled "Gold-catalyzed annulations of allenamides" and supervised by Prof. Mascareñas and Dr. López.It was a really successful defense at the Faculty of Chemistry (USC), getting the maximum qualification from the PhD committee.Many congrats to you, Iván!!
External link: https://www.usc.es/ciqus/es/noticias/las-tesis-del-ciqus-ivan-varela-sanda
