We are incredible happy to announce our last manuscript at Angew. Chem. Int. Ed., entitled "Palladium-Catalyzed Tandem Cycloisomerization/Cross-Couplingof Carbonyl- and Imine-Tethered Alkylidenecyclopropanes" and authored by F. Verdugo, R. Rodiño, M. Calvelo, J. L. Mascarenas and F. Lopez has been accepted and it's already on-line.
Abstract: Pd(0) catalysts featuring phosphorous-based monodentate ligands can detour the reactivity of carbonyl-tethered alkylidenecyclopropanes (ACPs) from standard (3+2) cycloadditions towards tandem cycloisomerization / cross-coupling processes. This new reactivity lies on the formation of key π-allyl oxapalladacyclic intermediates, which are subsequently trapped with external nucleophilic partners, instead of undergoing canonical C-O reductive eliminations. Importantly, the use of imine-tethered ACP’s is also feasible. Therefore, the method provides a straightforward and stereoselective entry to a wide variety of highly functionalized cyclic alcohols and amines.
External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202202295