We are very happy to share our Chem. Commun. paper in collaboration with Vázquez & Vázquez research group, among others, has been accepted and it's already available through the journal website. This work is entitled "Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide" and authored by J. Gomez-Gonzalez, L. Martinez-Castro, J. Tolosa-Barrilero, A. Alcalde-Ordoñez, S. Learte-Aymamí, J. L. Mascareñas, J. C. García-Martínez, J. Martínez-Costas, J.-D. Maréchal, M. Vázquez and E. Vázquez.
Abstract: Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.
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