Our last publication at the Org. Biomol. Chem. journal is on-line
05/30/2019We are so pleased to annouce our communication to Organic & Biomolecular Chemistry, entitled "A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC" and authored by R. Calo, C. Penas, A. Jiménez-Balsa, E. Vázquez and J. L. Mascareñas, has been accepted and it's already available through the journal website.
Abstract: We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both routes allowed the efficient synthesis of a miniprotein which is capable of heterodimerizing with MAX, and replicate the DNA binding of the native protein. The versatility of the reported synthetic approach enabled the straightforward preparation of MYC and Omomyc analogues, as well as fluorescently labeled derivatives
External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/OB/C9OB01209E#!divAbstract