Our last publication at Angew. Chem. Int. Ed. is available on-line


We are very happy to share here that our research article at Angew. Chem. Int. Ed., entitled "Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes" and authored by A. Gutiérrez-González, P. Destito, J. R. Couceiro, C. Pérez-González F. López and J. L. Mascarenas, has been accepted and it's already available through the journal website.

Abstract: Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal

External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202103645