We are very happy to share here that our research article at J. Phys. Chem. Lett., entitled "Surface-enhanced Raman Scattering Detection of Nucleic Acids exhibiting Sterically Accessible Guanines using Ruthenium-polypyridyl Reagents" and authored by and M. Martínez-Calvo, L. Guerrini, J. Rodríguez, R. A. Álvarez-Puebla and J. L. Mascarenas, has been accepted and it's already available through the journal website.
Abstract: Here, we report the application of surface-enhanced Raman scattering (SERS) spectroscopy as a rapid and practical tool for assessing the formation of coordinative adducts between nucleic acid guanines and ruthenium polypyridyl reagents. The technology provides a practical approach for the wash-free and quick identification of nucleic acid structures exhibiting sterically accessible guanines. This is demonstrated for the detection of a quadruplex-forming sequence present in the promoter region of the c-myc oncogene, which exhibits a non-paired, reactive guanine at a flanking position of the G-quartets.
External link: https://pubs.acs.org/doi/abs/10.1021/acs.jpclett.0c02148