Our first publication for this brand new 2022 is on-line


We are really pleased to announce here that our research article at RSC Adv., entitled "Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage" and authored by J. Rodríguez, C. Pérez-González, M. Martínez-Calvo, J. Mosquera and J. L. Mascarenas has been accepted and it's already on-line (gold Open Access).

Abstract: Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of palladium reagents that trigger the cleavage of the spacer, and the release of unfunctional monomeric peptides.

External link: https://pubs.rsc.org/en/content/articlelanding/2022/ra/d1ra09180h