We are really pleased to announce here that our research article at J. Am. Chem. Soc., entitled "Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis" and authored by C. D'Avino, S. Gutiérrez, M. J. Feldhaus, M. Tomás-Gamasa and J. L. Mascareñas has been accepted and it's already on-line (gold Open Access).
Abstract: Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.
External link: https://pubs.acs.org/doi/10.1021/jacs.3c13647