Our brand new article at Chem. Sci. is already available on-line


We are very glad to share here that our article at Chem. Sci., entitled "Ruthenium-Catalyzed Intermolecular Alkene-Alkyne Couplings in Biologically Relevant Media" and authored by A. Gutiérrez, D. Marcos, L. Cool, F. López and J. L. Mascarenas, is already available through the journal website.

Abstract: Cationic cyclopentadienyl Ru(II) catalysts can efficiently promote mild intermolecular alkyne-alkene couplings in aqueous media, even in the presence of different biomolecular components, and in complex media like DMEM. The method can also be used for the derivatization of aminoacids and peptides, therefore proposing a new way to label biomolecules with external tags. This C-C bond-forming reaction, based on simple alkene and alkyne reactants, can now be added to the toolbox of bioorthogonal reactions promoted by transition metal catalysts.

External link: https://pubs.rsc.org/en/Content/ArticleLanding/2023/SC/D3SC01254A