Brand new collaborative article with our Chilenians colleagues at Adv. Synth. Catal., is now available on-line through the journal website
08/21/2024We are really glad to announce here that our last collaborative article at the journal Adv. Synth. Catal., entitled "Palladium-Catalyzed Cross-Coupling between Alkylidenecyclopropanes and Boronic Acids" and authored by R. Rodiño, F. Mardones, K. Paredes, C. A. Jiménez, R. Nelson, J. L. Mascareñas, F. López and F. Verdugo, is already available through the publisher website as a gold-open access paper.
Abstract: The combination of a Pd(0) source and a phosphoramidite ligand promotes a formal allylic cross-coupling between alkylidenecyclopropanes (ACPs) and boronic acids to yield synthetically appealing 1,1-disubstituted alkenes. Remarkably, the reaction proceeds both under neutral and basic conditions, and works with both aryl- and alkenylboronic acids. DFT calculations suggest that the reaction entails a C-C activation/protonation mechanism instead of a hydropalladation pathway, such as has been proposed for other metal-promoted hydrofunctionalizations of ACPs.
External link: https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202400657