Another collaborative paper for 2025, this time at ACS Catalysis, is already available on-line
05/10/2025We are so happy to announce here that our collaborative research article at ACS Catal., entitled "Streamlined Identification of Metallopeptides for Intracellular Catalysis Using Positionally Addressable Combinatorial Libraries" and authored by C. González-González, L. Martínez-Castro, S. Learte-Aymamí, C. Pose-Insua, J. R. Couceiro, P. Martin-Malpartida, M. J. Macias, J.-D. Maréchal, J. L. Mascareñas and M. E. Vázquez, has been accepted and it's already on-line as a Gold-OA paper.
Abstract: The discovery and development of artificial catalysts to carry out bioorthogonal reactions in living cells is a primary goal at the interface of Chemistry and Biology. Current approaches rely on time-consuming trial-and-error methods. As an alternative, we show that positionally addressable combinatorial libraries (SPOT libraries) provide a significant advantage for the efficient identification of novel catalytic metallopeptides. Using these libraries, we were able to rapidly identify catalytic β-hairpin palladopeptides capable of promoting efficient depropargylation reactions in challenging intracellular environments.
External link: https://pubs.acs.org/doi/10.1021/acscatal.5c00525