After summer-brake, our last article "Axially Chiral 2-Hydroxybiaryls by Palladium-Catalyzed Enantioselective C–H Act" is now available on-line

10/16/2023

We are very glad to share here that our article at ACS Catal., entitled "Axially Chiral 2-Hydroxybiaryls by Palladium-Catalyzed Enantioselective C–H Activation" and authored by P. Losada, L. Goicoechea, J. L. Mascareñas and M. Gulías, is already available through the journal website.

Abstract: This article describes the discovery and development of a palladium-catalyzed asymmetric C–H olefination of 2-hydroxybiaryls. The strategy allows a direct assembly of optically active, axially chiral 2-substituted-2′-hydroxybiaryls from readily available precursors and demonstrates that the native hydroxy unit of the substrates can work as an efficient directing group for the C–H activation. This represents a substantial advantage over other approaches that require the preinstallation of metal coordinating units. The simplicity of the approach and versatility of the products allow a practical and efficient synthesis of a broad variety of optically active binaphthyl derivatives

External link: https://pubs.acs.org/doi/10.1021/acscatal.3c03867