A brand new stand-alone chapter in the prestigious Reference Collection in Chemistry, Molecular Sciences and Chemical Engineering is now available on-line

01/08/2024

We are so happy to announce here the work "Catalytic Addition of C–H Bonds Across C–C π-Bonds" authored by A. Arribas, C. Lázaro-Milla, J. L. Mascareñas and F. López, is already available through the website of Reference Collection in Chemistry, Molecular Sciences and Chemical Engineering as a stand-alone chapter


Abstract: Transition metal-catalyzed hydrocarbonations of C−C unsaturated substrates, namely the addition of a C–H bond across an unsaturated system, have emerged as powerful synthetic tools to increase molecular complexity. Those processes involving the oxidative addition of the C–H bond to the metal catalyst are particularly interesting due to their simplicity and an atom-economy. Albeit this field was traditionally dominated by low valent rhodium and ruthenium catalysts, in recent years, there have been many reports based on the use of iridium, nickel, cobalt and even iron complexes. In many cases, these reactions have a different course depending on the metal and ancillary ligands used. In this review, we aim to provide a detailed and informative journey, from the early pioneering examples in the field, most of them based on ruthenium, to the most recent developments. The review is organized by the type of C–H bond that is activated (with C sp2, sp or sp3), as well as by the metal catalyst and C–C unsaturated system that is used as hydrocarbonation partner (alkene, allene, diene or alkyne). Importantly, we discuss the mechanistic foundations of the methods, highlighting the differences between metals catalysts, and emphasize the current opportunities.




External link: https://www.sciencedirect.com/science/article/abs/pii/B9780323960250000193?via%3Dihub