A brand new Org. Lett. article is already available on-line
04/07/2026We are so pleased to announce here that our recent research article at Organic Letters, entitled "Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C–H Alkenylation" and authored by P. Losada, J. L. Mascareñas and M. Gulías, has been accepted and it's already on-line (gold Open Access).
Abstract: A concise, nine-step total synthesis of isoriccardin C and isoriccardin D has been developed. The strategy centers on the sequential installation of the four aromatic rings of the backbone by using three key transformations: Suzuki coupling, Wittig olefination, and Ullmann coupling. The pivotal step is a palladium(II)-catalyzed, intramolecular ortho-alkenylation that forges the 18-membered macrocyclic core. This streamlined route enables the total synthesis with minimal reliance on protecting groups, and its modular nature offers a versatile platform for the construction of structural analogues.
External link: https://pubs.acs.org/doi/10.1021/acs.orglett.6c00911