A brand new Org. Biomol. Chem. article is already available on-line
04/16/2025We are so happy to announce here that our recent research article at Organic & Biomolecualr Chemistry, entitled " Red-shifted photoredox generation and trapping of alkyl radicals towards bioorthogonality" and authored by D. Montoto, U.
Deus-Lorenzo, M. Tomás-Gamasa, J. L. Mascareñas and M. Mato, has been accepted and it's already on-line (gold Open Access).
Abstract: The photocatalytic generation and trapping of alkyl radicals is a powerful synthetic tool in organic chemistry, but it remains underexplored in biological settings. Here, we present two photoredox systems that leverage green- or red-light irradiation for the activation and subsequent Giese coupling of redox-active alkyl phthalimide esters. Besides utilizing mild low-energy light sources, these reactions operate with biocompatible BnNAH or NADH as electron donor. Notably, they display compatibility with air, water and biologically relevant conditions, including cell-culture media or even cell lysates. This work marks a significant step towards integrating synthetic alkyl-radical chemistry into biological settings.
External link: https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob00476d