So glad to announce our first 2023 paper and also collaborative work is already published on-line
We are very happy to share our Angew. Chem. Int. Ed. paper in
collaboration with Jimenez-Osés research group
has been accepted and it's already available through the journal
website. This work is entitled "Iridium-Catalyzed ortho-Selective Borylation of Aromatic Amides Enabled by 5-Trifluoromethylated Bipyridine Ligands" and authored by D. Marcos-Atanes, C. Vidal, C. Navo, F. Pecatti, G. Jiménez-Osés and J. L. Mascareñas.
Abstract: Iridium-catalyzed borylations of aromatic C–H bonds are highly
attractive transformations owing to the diversification possibilities
offered by the resulting boronates. These transformations are best
carried out using bidentate bipyridine or phenanthroline ligands, and
tend to be governed by steric factors, therefore resulting in the
competitive functionalization of meta and/or para positions. We have now
discovered that a subtle change in the bipyridine ligand, namely, the
introduction of a CF3 substituent at position 5, enables a complete
alteration of regioselectivity in the borylation of aromatic amides,
providing for the synthesis of a wide variety of ortho-borylated
derivatives. Importantly, thorough computational studies suggest that
the exquisite regio- and chemoselectivity stems from unusual
outer-sphere interactions between the amide group of the substrate and
the CF3–substituted aryl ring of the bipyridine ligand.
External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202214510
