News

Please find below all relevant news regarding our Group.
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ACS Catalysis. Third over the last 40 days... good job guys!!

07/10/2018
We are very glad to announce we got our third consecutive publication accepted at ACS Catalysis, in just fourty days.

Already available on-line our last publication at ACS catalysis by D. F. Fernández, C. A. B. Rodrigues, M. Calvelo, M. Gulías, J. L. Mascareñas and F. López, entitled "Iridium(I)-Catalyzed Intramolecular Cycloisomerization of Enynes: Scope and Mechanistic Course"

Abstract:
We report an Ir(I)-catalyzed cycloisomerization methodology that provides access to carbocyclic systems bearing exo-alkene moieties from alkynyl-equipped acyclic precursors. The method relies on the C-H activation of olefinic and (het-ero)aromatic C(sp2)–H bonds, followed by an exo-cyclization to a tethered alkyne, and provides interesting cyclic diene products that are amenable of further elaboration. Importantly, DFT calculations suggests that, in contrast to related hydrocarbonations of alkenes in which either migratory insertions or C-C reductive eliminations have been suggested to be rate determining, in our reac-tions, the energetic barrier of these steps is lower than that of the previous C–H activation.

External link: https://pubs.acs.org/doi/abs/10.1021%2Facscatal.8b02139

Our last publication at ACS Catalysis among the ACS editor’s choice articles

06/16/2018
Our latest letter to ACS Catalysis selected from acrossall ACS journals by ACS editors for its potential broad public interest

"Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands", authored by M. Martínez-Calvo, J. R. Couceiro, P. Destito, J. Rodriguez, J. Mosquera and J. L. Mascareñas, is our latest paper at ACS Catalysis.

Abstract:
Discrete palladium (II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. The performance of these complexes is superior to that of other palladium sources, which apparently are rapidly deactivated in such hostile complex media. This good balance between reactiv-ity and stability allows the use of these discrete phosphine palladium complexes in living mammalian cells, whereby they can mediate similar transformations. The presence of a phosphine ligand in the coordination sphere of palladi-um also provides for the introduction of targeting groups, such as hydrophobic phosphonium moieties, which facili-tate the accumulation of the complexes in mitochondria.



External link: https://pubs.acs.org/doi/10.1021/acscatal.8b01606

Congrats to María, who got the best oral communication award at the XI ISOMC "Marcial Morena Mañas", held in Oviedo

06/08/2018
Our colleague Dr. María Tomas-Gamasa has received the best oral communication prize at the XI international school in organometallic chemistry

Our group member Dr. María Tomás-Gamasa was awarded in Oviedo with the best oral communication prize at the XI International School on Organometallic Chemistry "Marcial Moreno Mañas", 6th-8th of June 2018.

The title of her communication was: "Ruthenium promoted reactions inside living cells", and she described the first examples of [2+2+2] cycloaddition reactions involving two exogenous, freely spreading substrates promoted by discrete ruthenium complexes inside living cells.


Another publication by the group in ACS Catalysis

06/07/2018
Already available in ASAP our last letter to ACS Catalysis

"Enantioselective Palladium-Catalyzed [3C + 2C] and [4C + 3C] Intramolecular Cycloadditions of Alkylidenecyclopropanes" by F. Verdugo, L. Villarino, J. Durán, M. Gulías, J. L. Mascareñas and F. López is already available on-line

ABSTRACT: We report a highly enantioselective [3C + 2C] intramolecular cycloaddition of alkylidenecyclopropanes (ACPs) and alkenes. The best results are obtained by using sterically demanding chiral phosphoramidite ligands derived from Vapol. Moreover, we also show that related, but less bulky, phosphoramidites can also lead to very effective [4C + 3C] cycloadditions when dienes, instead of alkenes, are used as reacting partners. The reactions provide a practical, simple, and selective access to optically active, synthetically appealing 5,5- and 5,7-bicyclic systems.


External link: https://pubs.acs.org/doi/10.1021/acscatal.8b01296

Just accepted our last paper in Angew. Chem. Int. Ed.

05/08/2018
Our latest communication in ACIE is ready for publishing

"Rhodium(III)‐Catalyzed Annulation of 2‐Alkenylanilides with Alkynes via C‐H Activation: a Direct Access to 2‐substituted Indolines" by Font, M., Cendón, B., Seoane, A., Mascareñas, J.L., and Gulías, M., is our recent communication to Angewandte Chemie International Edition

Abstract:
A Rh(III) complex featuring an electron‐deficient η5‐cyclopentadienyl ligand catalyzes an unusual annulation between alkynes and 2‐alkenylanilides, to form synthetically appealing 2‐substituted indolines. Formally, the process can be viewed as an allylic amination with concomitant hydrocarbonation of the alkyne. Mechanistic experiments indicate that this transformation involves a peculiar Rhodium migration with a concomitant 1,5‐H shift.

External link: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201802830

Goodbye Noelia Casanova

04/09/2018
Noelia Casanova left the group and she joined the University of Cambridge (UK) with Dr. Robert Phipps. Good luck Noelia!

Noelia Casanova left the group and she joined the University of Cambridge (UK) with Dr. Robert Phipps.
Good luck Noelia!

Nice collaboration with the research group of Liz-Marzán (CIC biomaGUNE, San Sebastian) and the former PhD student of our group Jesus Mosquera

03/21/2018
Already on-line our last publication in J. Am. Chem. Soc. This paper comes from a collaborative project with the group of Prof. L. M. Liz-Marzán.

A collaborative research paper, entitled Cellular Uptake of Gold Nanoparticles Triggered by Host–Guest Interactions, leaded by Dr. J. Mosquera (former PhD student in our group) from the group of Prof. L.M. Liz-Marzán at CIC biomaGUNE (San Sebastián, Spain) has been recently accepted in the J. Am. Chem. Soc.

External link: https://pubs.acs.org/doi/full/10.1021/jacs.7b12505