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Our first publication for 2020 is already on-line

02/14/2020
Really pleased to announce our latest ACS Catal. paper is available as a just accepted manuscript

Starting this brand new 2020 year... we are glad to announce our most recent publication at ACS Catalysis journal, entitled "Palladium-catalyzed formal (4+2) cycloaddition between alkyl amides and dienes initiated by the activation of C(sp3)−H bonds" and authored by B. Cendón, M. Font, J. L. Mascareñas and M. Gulías, is already available as just accepted manuscript.


Abstract:
We report a formal (4+2) cycloaddition between alkyl-nosylamides and dienes enabled by a palladium-catalyzed activation of C(sp3)−H bonds beta to the amide group. This atom economical reaction which proceeds under operationally simple conditions, is compatible with a wide variety of dienes, and provides a straightforward method to assemble different types of saturated lactams. The annulation is favored over alternative pathways in part because of the key role of the extra double bond of the diene partner. The use of suitable nitrogen-based additives as palladium ligands, which enable the C(sp3)−H activation without interfering in subsequent steps of the catalytic cycle, is also critical for the success of the reaction.


External link: https://twitter.com/MetBioCat/status/1230768577738764290

Goodbye Iván Varela

11/15/2019
Iván Varela Sandá has left the group and he joined the Leibniz-FMP (Germany). Good luck Iván!

Iván Varela Sandá has left the group and he joined the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Germany) for a postdoctoral position with Prof. Christian Hackenberger.

Good luck Iván!