News

Please find below all relevant news regarding our Group.
Click on a headline in order to read the full article.

Two further papers accepted over the last ten days, great! And both are open access

10/28/2021
So happy to announce our last review at ACIE and also a colaborative paper with Del Pino group at ACSnano are already available on-line

Here it is the short info for each of the articles.

ACSnano: "Plasmonic-Assisted Thermocyclizations in Living Cells Using Metal−Organic Framework Based Nanoreactors", authored by C. Carrillo-Carrión, R. Martínez, E. Polo, M. Tomás , P. Destito, M. Ceballos, B. Peláz, F. López, J. L. Mascareñas, P. Del Pino.

Angew. Chem. Int. Ed.: "Transition-Metal-Catalyzed Annulations Involving the Activation of C(sp3)−H Bonds", authored by M. Font, M. Gulías, J. L. Mascareñas.



External link: https://pubs.acs.org/doi/10.1021/acsnano.1c07983

Our former PhD student, and 'Xunta de Galicia' postdoctoral fellow, David F. Fernández has been working for almost two years in the research group of the brand-new Nobel Laureate David W. MacMillan

10/06/2021
David MacMillan, postdoctoral supervisor of David F. Fernández, has been awarded with the 2021 Nobel Prize in Chemistry

David F., nowadays a postdoc researcher at MacMillan's lab, received his PhD on July 2019 under the supervision of Prof. Mascareñas, Dr. López and Prof. Gulías, at the University of Santiago de Compostela. In 2017, he also performed a short stay at MacMillan's lab during his predoctoral stage.


He has been conducting his postdoctoral research at Princenton since January 2020, under the supervision of Dave MacMillan, 2021 Nobel Prize in Chemistry, thanks to the funding from the 'Xunta de Galicia'. During 2+1 years duration of this fellowship he will complete his first postdoc stage, also under the cosupervision of Prof. Mascareñas.




External link: https://www.gciencia.com/ciencia/cientifico-lucense-no-equipo-do-nobel-de-quimica/

RSEQ-symposium-2021

09/26/2021
The contribution of our lab members to the RSEQ symposium has started today with the short-lecture of Soraya, 2021 Lilly-RSEQ Awards PhD Students

2021 RSEQ symposium started today and our lab member, Soraya Learte-Aymamí, has given her short-lecture at the Lilly session during this opening morning (11:15).

Congrats again to Soraya, 2021 Lilly-RSEQ Awardee for PhD Students,
who has shortly presented her PhD work during her talk entitled "Metallopeptides and metalloproteins in chemical biology: from DNA binding to intracellular catalysis" (https://twitter.com/MetBioCat/status/1442428275083472896)

So proud of you, Soraya!


Some other members of the group are also presenting their contributions as oral, flash or poster communications.

Hope you all enjoy the conference!!





External link: https://rseqsymposium2021.com/program

Our new mini-review at Trends Chem. is available on-line

09/25/2021
We are so happy to announce our last mini-review highlighting "(4 + 2) Cycloadditions via Pd C(sp3)–H activation" is already at the journal website

We are very glad to share here that our "Mechanism of the Month" piece at Trends Chem., entitled "(4 + 2) Cycloadditions via Pd C(sp3)–H activation" and authored by X. Vidal, M. Font, B. Cendón, J. L. Mascarenas and M. Gulias, is already available through the journal website.

NOTE: You might access to the lastest version of the article at ScienceDirect by using the following link: https://authors.elsevier.com/c/1dp4-9CpcYOzmZ, which will be available until November 13th, 2021




External link: https://www.sciencedirect.com/science/article/abs/pii/S2589597421001763

Our last publication at Angew. Chem. Int. Ed. is available on-line

06/16/2021
We are very glad to announce our last paper about bioorthogonal chemical reactions is at ANIE Early view

We are very happy to share here that our research article at Angew. Chem. Int. Ed., entitled "Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes" and authored by A. Gutiérrez-González, P. Destito, J. R. Couceiro, C. Pérez-González F. López and J. L. Mascarenas, has been accepted and it's already available through the journal website.

Abstract: Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal








External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202103645

Congrats to David, on his successful PhD defense

05/28/2021
David Cagiao Marcote has defended today his PhD Thesis at the Faculty of Chemistry, USC

David Cagiao Marcote is our brand new Doctor in the group, after defending his PhD entitled "Novas Estratexias Sintéticas Baseadas en Catálise de Ouro".

This PhD work, supervised by Prof. Mascareñas and Dr. López, has received the highest qualification by the jury committee.

Congrats David!!!




External link: https://twitter.com/ciqususc/status/1398252322191458306

Our new paper at Bioorg. Chem. in colaboration with Prof. Mollica is already on-line

03/22/2021
So happy to share our last collaboration with Mollica's group is already published in the Bioorganic Chemistry journal

We are very glad to announce here that our research article at Bioorg. Chem. in collaboration with Mollica's group, entitled "A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA" and authored by A. Stefanucci, J. Amato, D. Brancaccio, B. Pagano, A. Randazzo, F. Santoro, L. Mayol, S. Learte, J. Rodríguez, J. L. Mascareñas, E. Novellino, A. Carotenuto and A. Mollica, has been accepted and it's already available through the journal website.

Abstract: Transcription factors (TFs) have a remarkable role in the homeostasis of the organisms and there is a growing interest in how they recognize and interact with specific DNA sequences. TFs recognize DNA using a variety of structural motifs. Among those, the ribbon-helix-helix (RHH) proteins, exemplified by the MetJ and ARC repressors, form dimers that insert antiparallel β-sheets into the major groove of DNA. A great chemical challenge consists of using the principles of DNA recognition by TFs to design minimized peptides that maintain the DNA affinity and specificity characteristics of the natural counterparts. In this context, a peptide mimic of an antiparallel β-sheet is very attractive since it can be obtained by a single peptide chain folding in a β-hairpin structure and can be as short as 14 amino acids or less. Herein, we designed eight linear and two cyclic dodeca-peptides endowed with β-hairpins. Their DNA binding properties have been investigated using fluorescence spectroscopy together with the conformational analysis through circular dichroism and solution NMR. We found that one of our peptides, peptide 6, is able to bind DNA, albeit without sequence selectivity. Notably, it shows a topological selectivity for the major groove of the DNA which is the interaction site of ARC and many other DNA-binding proteins. Moreover, we found that a type I’ β-hairpin folding pattern is a favorite peptide structure for interaction with the B-DNA major groove. Peptide 6 is a valuable lead compound for the development of novel analogs with sequence selectivity.

See limited-time downloadable version at https://authors.elsevier.com/c/1cqckAHs8WTkL



External link: https://www.sciencedirect.com/science/article/abs/pii/S0045206821002133