Second in a row: another collaborative article, this time at Org. Lett., is now available on-line
11/10/2023Abstract: Cobalt(I) catalysts equipped with bisphosphine ligands can be used to
promote formal (3 + 2 + 2) intramolecular cycloadditions of
enynylidenecyclopropanes of type 1. The method provides
synthetically appealing 5,7,5-fused tricyclic systems in good yields and
with complete diastereo- and chemoselectivity. Interestingly, its scope
differs from that of previously reported annulations based on precious
metal catalysts, specifically rhodium and palladium. Noticeably, density
functional theory calculations confirm that the mechanism of the
reaction is also different from those proposed for these other catalysts.
External link: https://pubs.acs.org/doi/10.1021/acs.orglett.3c03511