Congratulations ot our group leader, for his recent 2025 Rei Jaume I prize
06/03/2025External link: https://fprj.es/mascarenas-eeckhout-lopez-bigas-reyes-vicent-tormo-y-de-sanjose-son-los-premiados-de-la-37-edicion/
Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.
Education of researchers in order they become
future leaders of academic or industrial projects.
Transferring of knowledge to Society in order
to propel economical and social progress
External link: https://fprj.es/mascarenas-eeckhout-lopez-bigas-reyes-vicent-tormo-y-de-sanjose-son-los-premiados-de-la-37-edicion/
Abstract: We report a versatile, highly enantioselective intramolecular hydroarylation of allenyl-tethered pyrroles and indoles. The reaction, promoted by an iridium(I)/bisphosphine chiral catalyst, provides a direct access heteropolycyclic systems bearing either tertiary or quaternary carbon stereocenters and a synthetically appealing alkenyl pendant. The method allows a highly efficient assembly of five-, six- and even seven-membered fused indole and pyrrole products, providing enantiomeric excesses of up to 99%. DFT computational studies align nicely with the experimental results and allow to rationalize the key factors that control both regio- and stereoselectivity of the process. Finally, the synthetic potential of the method was exemplified with a very short, highly enantioselective formal synthesis of (+)-Rhazinilam
External link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202508252
External link: https://www.usc.es/ciqus/en/news/ciqus-stands-out-prestigious-burgenstock-conference
Abstract: The discovery and development of artificial catalysts to carry out bioorthogonal reactions in living cells is a primary goal at the interface of Chemistry and Biology. Current approaches rely on time-consuming trial-and-error methods. As an alternative, we show that positionally addressable combinatorial libraries (SPOT libraries) provide a significant advantage for the efficient identification of novel catalytic metallopeptides. Using these libraries, we were able to rapidly identify catalytic β-hairpin palladopeptides capable of promoting efficient depropargylation reactions in challenging intracellular environments.
External link: https://pubs.acs.org/doi/10.1021/acscatal.5c00525
José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.
Group MembersWe are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.
OpportunitiesAnnual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.
Students attend the University. With the city population around 100,000.
Year old University. Currently imparting more than 60 degrees.
Santiago is well connected, having its own international airport, train station, etc.
Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.
Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.
Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.
Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.
Official websites:
University of Santiago
Santiago Tourism
CIQUS