Chemical Biology Metal Catalysis

Our Aims

Generation, training and transfer of knowledge

Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.

Education of researchers in order they become
future leaders of academic or industrial projects.

Transferring of knowledge to Society in order
to propel economical and social progress

European Research Council Santiago de Compostela University Campus Vida CIQUS - Centro Singular de Investigación en Química Biológica y Materiales Moleculares
Latest News
Media Library

Already available our last publication at Chem. Sci.

08/01/2019
We are very pleased to announce our latest collaboration with Prof. M. E. Vázquez, Dr. M. Melle-Franco and Prof. M. Vázquez has been published

Glad to announce our most recent publication at the Chem. Sci. journal, entitled "Canonical DNA minor groove insertion of bisbenzamidine-Ru(II) complexes with chiral selectivity" and authored by M.I. Sanchez, G. Rama, R. Calo-Lapido, K. Ucar, P. Lincoln, M. Vázquez, M. Melle-Franco, J. L. Mascareñas  and M. E. Vázquez, is already available.

Abstract: We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)2b4bpy]2+, Δ‑4Ru) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.



External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/SC/C9SC03053K#!divAbstract

Our last publication at Org. Process Res. Dev., part of the "Special Issue Honoring 25 Years of the Buchwald-Hartwig Amination", is available on-line

07/15/2019
Happy to announce our Organic Process Research & Development brand new manuscript it's already on-line

So pleased to share we have our last paper at Organic Process Research & Development accepted. It is entitled "Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions" and authored by Prof. Moisés Gulías, Daniel Marcos-Atanes, Prof. José L. Mascareñas and Dr. Marc Font

Abstract: Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadings.



External link: https://pubs.acs.org/doi/10.1021/acs.oprd.9b00191

Congrats Iván, it's been a great morning!

07/15/2019
Iván Varela Sandá has defended his PhD Thesis today, July the 15th

Iván Varela Sandá has defended today his PhD Thesis, entitled "Gold-catalyzed annulations of allenamides" and supervised by Prof. Mascareñas and Dr. López.

It was a really successful defense at the Faculty of Chemistry (USC), getting the maximum qualification from the PhD committee.

Many congrats to you, Iván!!



External link: https://www.usc.es/ciqus/es/noticias/las-tesis-del-ciqus-ivan-varela-sanda

Congrats to David, on his successful PhD defense

07/12/2019
David Fernández Fernández has defended today his PhD Thesis at the Faculty of Chemistry, USC

David Fernández Fernández is our brand new Doctor in the group, after defending his PhD entitled "Transition Metal Catalyzed Annulations Based on The Activation of C–H Bonds".

This PhD work, supervised by Prof. Mascareñas, Dr. López and Prof. Gulías, has received the highest qualification by the jury committee.

Congrats David!!!


External link: https://www.usc.es/ciqus/es/noticias/las-tesis-del-ciqus-david-f-fernandez

Synthetic models in Chemical Biology

08/23/2019
Workshop on Nanomedicine 2012. Prof. Mascareñas, ERC - Advanced Grant METBIOCAT, explains his research lines in the chemical biology field.
DNA is the key macromolecule used by nature to store the genetic information, therefore containing all the instructions that control the day-to-day function of cells. As such, it has been a traditional target for the development of different type of drugs, particularly anticancer agents. These drugs include alkylating agents, like cis-platinum and derivatives, and non-covalent binders like the anthracyclines, which interact to DNA by intercalation between base pairs. There are other types of cytotoxic non-covalent DNA binders, like distamycin or propamidine, which interact to DNA by insertion in the minor groove.

We have been interested in this latter type of molecules, because they are sequence selective and therefore provide for molecular engineering of site-specific DNA-promoted processes. In particular, we have designed and synthesized a number of variants of propamidine that work as sequence specific DNA optical sensors, or as light-activated prodrugs.

Some of the knowledge acquired in the studies of light-promoted processes has been extended to area of DNA-protein interactions. In particular, we have developed a chemical approach to control the DNA interaction of synthetic mimics of transcription factors, and expect that the tactic can be used in the future to regulate processes of gene expression.
Part of our work in this area is also focused to the construction of optical sensors that can detect minute amounts of transcription factors considered as oncogenic biomarkers, like the bZIP protein Jun.

Meet our team

José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.

Group Members

Join Us

We are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.

Opportunities

Living and working in
Santiago de Compostela

Are you new to the city and its University?
We have gathered some facts and figures you may find interesting.

15ºC

Annual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.

33,000

Students attend the University. With the city population around 100,000.

500

Year old University. Currently imparting more than 60 degrees.

Connected

Santiago is well connected, having its own international airport, train station, etc.

Heritage

Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.

Galicia

Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.

Transport

Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.

Language

Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.

Resources

Official websites:
University of Santiago
Santiago Tourism
CIQUS