Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.
Education of researchers in order they become
future leaders of academic or industrial projects.
Transferring of knowledge to Society in order
to propel economical and social progress
Abstract: We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc finger modules and an AT-hook linking peptide. The computational study provides for the first time a structural view of these types of complexes, dissecting interactions that are key to modulate their stability. The relevance of these interactions was validated experimentally. These results confirm the potential of this type of computational approach for studying peptide–DNA complexes and suggest that they could be very useful for the rational design of non-natural, DNA binding miniproteins.
Abstract: Cationic cyclopentadienyl Ru(II) catalysts can efficiently promote mild intermolecular alkyne-alkene couplings in aqueous media, even in the presence of different biomolecular components, and in complex media like DMEM. The method can also be used for the derivatization of aminoacids and peptides, therefore proposing a new way to label biomolecules with external tags. This C-C bond-forming reaction, based on simple alkene and alkyne reactants, can now be added to the toolbox of bioorthogonal reactions promoted by transition metal catalysts.
José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.Group Members
We are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.Opportunities
Annual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.
Students attend the University. With the city population around 100,000.
Year old University. Currently imparting more than 60 degrees.
Santiago is well connected, having its own international airport, train station, etc.
Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.
Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.
Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.
Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.