Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.
Education of researchers in order they become
future leaders of academic or industrial projects.
Transferring of knowledge to Society in order
to propel economical and social progress
Abstract:We report an Ir(I)-catalyzed cycloisomerization methodology that provides access to carbocyclic systems bearing exo-alkene moieties from alkynyl-equipped acyclic precursors. The method relies on the C-H activation of olefinic and (het-ero)aromatic C(sp2)–H bonds, followed by an exo-cyclization to a tethered alkyne, and provides interesting cyclic diene products that are amenable of further elaboration. Importantly, DFT calculations suggests that, in contrast to related hydrocarbonations of alkenes in which either migratory insertions or C-C reductive eliminations have been suggested to be rate determining, in our reac-tions, the energetic barrier of these steps is lower than that of the previous C–H activation.
External link: https://pubs.acs.org/doi/abs/10.1021%2Facscatal.8b02139
"Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands", authored by M. Martínez-Calvo, J. R. Couceiro, P. Destito, J. Rodriguez, J. Mosquera and J. L. Mascareñas, is our latest paper at ACS Catalysis.
Abstract:Discrete palladium (II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. The performance of these complexes is superior to that of other palladium sources, which apparently are rapidly deactivated in such hostile complex media. This good balance between reactiv-ity and stability allows the use of these discrete phosphine palladium complexes in living mammalian cells, whereby they can mediate similar transformations. The presence of a phosphine ligand in the coordination sphere of palladi-um also provides for the introduction of targeting groups, such as hydrophobic phosphonium moieties, which facili-tate the accumulation of the complexes in mitochondria.
External link: https://pubs.acs.org/doi/10.1021/acscatal.8b01606
José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.Group Members
We are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.Opportunities
Annual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.
Students attend the University. With the city population around 100,000.
Year old University. Currently imparting more than 60 degrees.
Santiago is well connected, having its own international airport, train station, etc.
Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.
Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.
Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.
Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.