We are really pleased to announce here that our research article at ACS catal., entitled "Iridium-Catalyzed Tandem Dehydrogenation/Hydroarylation Approach to Synthetically Versatile C2-Alkenyl N–H Indoles" and authored by C. Lázaro-Milla, J. L. Mascareñas and F. López, has been accepted and it's already on-line (gold Open Access).

Abstract: Readily available N-carbamoyl indolines can be converted into highly valuable 2-alkenyl and 2-alkyl indoles in a one-pot reaction, through an autotandem catalytic cascade promoted by an iridium complex. The process entails a dehydrogenation reaction initiated by an iridium-promoted C(sp3)–H activation, the addition of the resulting indole to an alkyne -or alkene-partner, and a spontaneous loss of the carbamoyl directing group. Interestingly, the resulting C2-alkenyl indoles can participate in a variety of metal-catalyzed annulations initiated by C–H activation, including formal [4 + 1] and [4 + 2] cycloadditions, as well as cross-dehydrogenative cyclizations, thus enabling a divergent access to a collection of functionally rich nitrogen-containing heterocycles.

External link: https://pubs.acs.org/doi/10.1021/acscatal.3c05841

Abstract: The coordination complex Ru1 represents not only an exciting new anti-cancer agent, but also a molecular tool to dissect the role of OXPHOS in CSCs. Results indicating that the compound is safe, non-toxic and highly effective in vivo are extremely exciting, and have allowed us to uncover unprecedented mechanistic possibilities to fight different cancer types based on targeting CSC OXPHOS

External link: https://link.springer.com/article/10.1186/s13046-023-02931-7?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240127&utm_content=10.1186/s13046-023-02931-7

External link: https://scf-chembio2024.com/program/

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We are really pleased to announce here that our research article at J. Am. Chem. Soc., entitled "Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis" and authored by C. D'Avino, S. Gutiérrez, M. J. Feldhaus, M. Tomás-Gamasa and J. L. Mascareñas has been accepted and it's already on-line (gold Open Access).

Abstract: Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.

External link: https://pubs.acs.org/doi/10.1021/jacs.3c13647