Chemical Biology Metal Catalysis

Our Aims

Generation, training and transfer of knowledge

Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.

Education of researchers in order they become
future leaders of academic or industrial projects.

Transferring of knowledge to Society in order
to propel economical and social progress

European Research Council Santiago de Compostela University Campus Vida CIQUS - Centro Singular de Investigación en Química Biológica y Materiales Moleculares
Latest News
Media Library

Our last paper at 'The Journal of the American Chemical Society' is available as Article ASAP

We are very glad to announce our first 2021 J. Am. Chem. Soc. paper is already on-line

We are very happy to share here that our research article at J. Am. Chem. Soc., entitled "Kinetic Resolution of Allyltriflamides through a Pd-Catalyzed C–H Functionalization with Allenes: Asymmetric Assembly of Tetrahydropyridines" and authored by J. M. González, B. Cendón, J. L. Mascarenas and M. Gulías, has been accepted and it's already available through the journal website.

Abstract: Enantioenriched, six-membered azacycles are essential structural motifs in many products of pharmaceutical or agrochemical interest. Here we report a simple and practical method for enantioselective assembly of tetrahydropyridines, which is paired to a kinetic resolution of α-branched allyltriflamides. The reaction consists of a formal (4+2) cycloaddition between the allylamine derivatives and allenes and is initiated by a palladium(II)-catalyzed C–H activation process. Both the chiral allylamide precursors and the tetrahydropyridine adducts were successfully obtained in high yields, with excellent enantioselectivity (up to 99% ee) and selectivity values of up to 127.

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Our first publication for 2021 is on-line

Pleased to announce our most recent Angew. Chem. Int. Ed. manuscript has been accepted, and it's already available

We are very happy to share here that our research article at Angew. Chem. Int. Ed., entitled "Highly Enantioselective Cobalt‐Catalyzed (3 + 2) Cycloadditions of Alkynylidenecyclopropanes" and authored by E. Da Concepción, I. Fernández, J. L. Mascarenas and F. López, has been accepted and it's already available through the journal website.

Abstract: Low‐valent cobalt complexes equipped with chiral ligands can efficiently promote highly enantioselective (3+2) cycloadditions of alkyne‐tethered alkylidenecyclopropanes. The annulation allows to assemble bicyclic systems containing five‐membered rings in good yields and with excellent enantiomeric ratios. We also present a mechanistic discussion based on experimental and computational data, which support the involvement of Co(I)/Co(III) catalytic cycles

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One of our last publications at ACIE is getting plenty of attention

This VIP (Very Important Paper) at Angew. Chem. Int. Ed. shows a very complex chemical reaction run at the living cell for the very first time

This work, published by the beginning of July at Angew. Chem. Int. Ed. and authored by Joan Miguel, María Tomás and José Luis Mascareñas, has been considered as a Very Important Paper by the reviewers.

See some news at:

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Synthetic models in Chemical Biology

Workshop on Nanomedicine 2012. Prof. Mascareñas, ERC - Advanced Grant METBIOCAT, explains his research lines in the chemical biology field.
DNA is the key macromolecule used by nature to store the genetic information, therefore containing all the instructions that control the day-to-day function of cells. As such, it has been a traditional target for the development of different type of drugs, particularly anticancer agents. These drugs include alkylating agents, like cis-platinum and derivatives, and non-covalent binders like the anthracyclines, which interact to DNA by intercalation between base pairs. There are other types of cytotoxic non-covalent DNA binders, like distamycin or propamidine, which interact to DNA by insertion in the minor groove.

We have been interested in this latter type of molecules, because they are sequence selective and therefore provide for molecular engineering of site-specific DNA-promoted processes. In particular, we have designed and synthesized a number of variants of propamidine that work as sequence specific DNA optical sensors, or as light-activated prodrugs.

Some of the knowledge acquired in the studies of light-promoted processes has been extended to area of DNA-protein interactions. In particular, we have developed a chemical approach to control the DNA interaction of synthetic mimics of transcription factors, and expect that the tactic can be used in the future to regulate processes of gene expression.
Part of our work in this area is also focused to the construction of optical sensors that can detect minute amounts of transcription factors considered as oncogenic biomarkers, like the bZIP protein Jun.

Meet our team

José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.

Group Members

Join Us

We are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.


Living and working in
Santiago de Compostela

Are you new to the city and its University?
We have gathered some facts and figures you may find interesting.


Annual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.


Students attend the University. With the city population around 100,000.


Year old University. Currently imparting more than 60 degrees.


Santiago is well connected, having its own international airport, train station, etc.


Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.


Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.


Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.


Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.


Official websites:
University of Santiago
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