Chemical Biology Metal Catalysis

Our Aims

Generation, training and transfer of knowledge

Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.

Education of researchers in order they become
future leaders of academic or industrial projects.

Transferring of knowledge to Society in order
to propel economical and social progress

European Research Council Santiago de Compostela University Campus Vida CIQUS - Centro Singular de Investigación en Química Biológica y Materiales Moleculares
Latest News
Media Library

Starting February... first ACS Catalysis of 2024 year is hot off the press. And it's OA, have a look at it!

02/09/2024
Happy to share our brand new ACS Catal. manuscript has been accepted, and it's available as Open Access through the publisher website

We are really pleased to announce here that our research article at ACS catal., entitled "Iridium-Catalyzed Tandem Dehydrogenation/Hydroarylation Approach to Synthetically Versatile C2-Alkenyl N–H Indoles" and authored by C. Lázaro-Milla, J. L. Mascareñas and F. López, has been accepted and it's already on-line (gold Open Access).


This work is also dedicated, in memoriam, to Dr. Alejandro Gutiérrez González.

Abstract: Readily available N-carbamoyl indolines can be converted into highly valuable 2-alkenyl and 2-alkyl indoles in a one-pot reaction, through an autotandem catalytic cascade promoted by an iridium complex. The process entails a dehydrogenation reaction initiated by an iridium-promoted C(sp3)–H activation, the addition of the resulting indole to an alkyne -or alkene-partner, and a spontaneous loss of the carbamoyl directing group. Interestingly, the resulting C2-alkenyl indoles can participate in a variety of metal-catalyzed annulations initiated by C–H activation, including formal [4 + 1] and [4 + 2] cycloadditions, as well as cross-dehydrogenative cyclizations, thus enabling a divergent access to a collection of functionally rich nitrogen-containing heterocycles.


External link: https://pubs.acs.org/doi/10.1021/acscatal.3c05841

A brand new collaborative article, at J. Exp. Clin. Cancer Res., is now available on-line through the journal website

01/27/2024
Once again in a week! We are so happy to share another manuscript, this time in collaboration with B. Sainz Jr. group, is already available

We are really glad to announce here that our last collaborative article at the J. Exp. Clin. Cancer Res., entitled "Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy" and authored by S. Alcalá, L. Villarino, [...] (25 further authors), J. L. Mascareñas and B. Sainz J., is already available through the journal website as a gold-open access paper.

Do not miss these latest results for this joint project among B. Sainz Jr. research group and ours!


Abstract: The coordination complex Ru1 represents not only an exciting new anti-cancer agent, but also a molecular tool to dissect the role of OXPHOS in CSCs. Results indicating that the compound is safe, non-toxic and highly effective in vivo are extremely exciting, and have allowed us to uncover unprecedented mechanistic possibilities to fight different cancer types based on targeting CSC OXPHOS




External link: https://link.springer.com/article/10.1186/s13046-023-02931-7?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240127&utm_content=10.1186/s13046-023-02931-7

Participation of group members at the SCF Chembio Symp. 2024 in Paris

01/26/2024
These last three days we had six members of the group, including our group leader, at Paris for the SCF Chemical Biology Symposium 2024

Over the last three days, some of our group researchers: Alejandra, Cinzia, Adrián, Leonard and Fernando, together with Prof. Mascareñas, were attending the SCF Chembio Symp. 2024.

It's been a really nice event in the Université Paris Saclay, in which we have been also paying tribute through our contributions to our beloved Alejandro Gutiérrez-González, former member of the group.





External link: https://scf-chembio2024.com/program/

Our first paper of the year 2024 is on-line, and it's a JACS

01/26/2024
Happy to share our most recent J. Am. Chem. Soc. manuscript has been accepted, and it's available as Open Access through the publisher website

We are really pleased to announce here that our research article at J. Am. Chem. Soc., entitled "Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis" and authored by C. D'Avino, S. Gutiérrez, M. J. Feldhaus, M. Tomás-Gamasa and J. L. Mascareñas has been accepted and it's already on-line (gold Open Access).


This work is dedicated to the memory of our beloved PhD student and friend Alejandro Gutiérrez-González.

Abstract: Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.



External link: https://pubs.acs.org/doi/10.1021/jacs.3c13647

Synthetic models in Chemical Biology

05/24/2024
Workshop on Nanomedicine 2012. Prof. Mascareñas, ERC - Advanced Grant METBIOCAT, explains his research lines in the chemical biology field.
DNA is the key macromolecule used by nature to store the genetic information, therefore containing all the instructions that control the day-to-day function of cells. As such, it has been a traditional target for the development of different type of drugs, particularly anticancer agents. These drugs include alkylating agents, like cis-platinum and derivatives, and non-covalent binders like the anthracyclines, which interact to DNA by intercalation between base pairs. There are other types of cytotoxic non-covalent DNA binders, like distamycin or propamidine, which interact to DNA by insertion in the minor groove.

We have been interested in this latter type of molecules, because they are sequence selective and therefore provide for molecular engineering of site-specific DNA-promoted processes. In particular, we have designed and synthesized a number of variants of propamidine that work as sequence specific DNA optical sensors, or as light-activated prodrugs.

Some of the knowledge acquired in the studies of light-promoted processes has been extended to area of DNA-protein interactions. In particular, we have developed a chemical approach to control the DNA interaction of synthetic mimics of transcription factors, and expect that the tactic can be used in the future to regulate processes of gene expression.
Part of our work in this area is also focused to the construction of optical sensors that can detect minute amounts of transcription factors considered as oncogenic biomarkers, like the bZIP protein Jun.

Meet our team

José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.

Group Members

Join Us

We are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.

Opportunities

Living and working in
Santiago de Compostela

Are you new to the city and its University?
We have gathered some facts and figures you may find interesting.

15ºC

Annual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.

33,000

Students attend the University. With the city population around 100,000.

500

Year old University. Currently imparting more than 60 degrees.

Connected

Santiago is well connected, having its own international airport, train station, etc.

Heritage

Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.

Galicia

Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.

Transport

Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.

Language

Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.

Resources

Official websites:
University of Santiago
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CIQUS