In this Account, we present recent efforts on the development of platinum- and gold-catalyzed formal cycloadditions of allenes, only including annulations initiated by a direct metal-promoted activation of the allene moiety.This Account is organized considering the number of atoms engaged in the annulation process, and when possible, we present the results in a chronological order.

External link: https://pubs.acs.org/doi/10.1021/acs.accounts.8b00567

Glad to announce our most recent publication at the Journal of the American Chemical Society in this brand new 2019 year, entitled "Palladium-catalyzed, enantioselective formal cycloaddition between benzyltriflamides and allenes: Straightforward access to enantioen-riched isoquinolines" and authored by X. Vidal, J. L. Mascareñas and M. Gulías, is already available as just accepted manuscript.

Abstract:

Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when carried out in presence of designed N-protected amino acids as metal ligands. More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing, annulative C-H activations of prochiral diarylmethylphenyl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios.

External link: https://pubs.acs.org/doi/10.1021/jacs.8b12636

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles, and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki-Miyaura cross-couplings, in water, and under physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in presence of relatively high concentrations of biomolecular components, and even in the presence of mammalian cells.

External link: https://pubs.rsc.org/en/Content/ArticleLanding/2019/SC/C8SC04390F#!divAbstract

External link: http://www.bioga.org/nacen-los-premios-chemists-for-our-future-para-potenciar-el-talento-y-la-iniciativa-entre-los-universitarios-gallegos-de-quimica/?lang=es

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