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Summary:Translating the potential of transition metal catalysis to biological and living environments promises to have a profound impact in chemical biology and biomedicine. A major challenge in the field is the creation of metal-based catalysts that remain active over time. Here, we demonstrate that embedding a reactive metallic core within a microporous metal-organic framework-based cloak preserves the catalytic site from passivation and deactivation, while allowing a suitable diffusion of the reactants. Specifically, we report the fabrication of nanoreactors composed of a palladium nanocube core and a nanometric imidazolate framework, which behave as robust, long-lasting nanoreactors capable of removing propargylic groups from phenol-derived pro-fluorophores in biological milieu and inside living cells. These heterogeneous catalysts can be reused within the same cells, promoting the chemical transformation of recurrent batches of reactants. We also report the assembly of tissue-like 3D spheroids containing the nanoreactors and demonstrate that they can perform the reactions in a repeated manner.
Abstract:A Pd catalyst made from a Pd(0) source and a bulky biaryl phosphine ligand promotes highly efficient intramolecular (3 + 2) heterocycloadditions between alkylidenecyclopropanes (ACPs) and carbonyls. The annulations provide a straightfor-ward access to fused polycyclic systems featuring β-methylene tetrahydrofuran moieties. DFT data support a pallada-ene process and shed light on the critical role of hemilabile interactions between the Pd center and the bulky biaryl phosphine. Significantly, these Pd(0) catalysts are also effective for promoting intermolecular formal cycloadditions between ACPs and trifluoromethyl ketones, thus providing for a direct entry to chiral THFs bearing trifluoromethyl–substituted carbons
External link: https://pubs.acs.org/doi/10.1021/acscatal.0c01827
Abstract:We describe the nickel(II)‐mediated self‐assembly of a multimeric DNA binder composed by two metal‐chelating peptides derived from a bZIP transcription factor ( brHis 2 ) and one short AT‐hook domain equipped with two bipyridine ligands ( HkBpy 2 ). These peptides reversibly assemble in the presence of Ni(II) ions at selected DNA sequences of 13 base pairs.
José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.Group Members
We are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.Opportunities
Annual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.
Students attend the University. With the city population around 100,000.
Year old University. Currently imparting more than 60 degrees.
Santiago is well connected, having its own international airport, train station, etc.
Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.
Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.
Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.
Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.