We are very glad to announce our first Cell Rep. Phys. Sci. paper is already published. Take also a look to our cover for this issue no. 6
It's almost middle of 2020 year and we are very happy to share our first publication at the brand-new Cell Reports Physical Science journal, entitled "Core-Shell Palladium/MOF Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models" and authored by R. Martínez, C. Carrillo-Carrión, P. Destito, A. Álvarez, M. Tomás , B. Peláz, F. López, J. L. Mascareñas and P. Del Pino.
Summary:
Translating the potential of transition metal catalysis to biological
and living environments promises to have a profound impact in chemical
biology and biomedicine. A major challenge in the field is the creation
of metal-based catalysts that remain active over time. Here, we
demonstrate that embedding a reactive metallic core within a microporous
metal-organic framework-based cloak preserves the catalytic site from
passivation and deactivation, while allowing a suitable diffusion of the
reactants. Specifically, we report the fabrication of nanoreactors
composed of a palladium nanocube core and a nanometric imidazolate
framework, which behave as robust, long-lasting nanoreactors capable of
removing propargylic groups from phenol-derived pro-fluorophores in
biological milieu and inside living cells. These heterogeneous catalysts
can be reused within the same cells, promoting the chemical
transformation of recurrent batches of reactants. We also report the
assembly of tissue-like 3D spheroids containing the nanoreactors and
demonstrate that they can perform the reactions in a repeated manner.
External link: https://www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(20)30071-0#%20
