Development of creative and groundbreaking
research at the interface of Chemistry, Biology and Medicine.
Education of researchers in order they become
future leaders of academic or industrial projects.
Transferring of knowledge to Society in order
to propel economical and social progress
External link: https://twitter.com/MetBioCat/status/1305921149973327872
Abstract: Transition metal-catalyzed hydrocarbonations of unsaturated substrates have emerged as powerful synthetic tools for increasing molecular complexity in an atom-economical manner. Although this field was traditionally dominated by low valent rhodium and ruthenium catalysts, in recent years, there have been many reports based on the use of iridium complexes. In many cases, these reactions have a different course from those of their rhodium homologs, and even allow performing otherwise inviable transformations. In this review we aim to provide an informative journey, from the early pioneering examples in the field, most of them based on other metals than iridium, to the most recent transformations catalyzed by designed Ir(I) complexes. The review is organized by the type of C–H bond that is activated (with C sp2, sp or sp3), as well as by the C–C unsaturated partner that is used as a hydrocarbonation partner (alkyne, allene or alkene). Importantly, we discuss the mechanistic foundations of the methods highlighting the differences from those previously proposed for processes catalyzed by related metals, particularly those of the same group (Co and Rh).
External link: https://pubs.rsc.org/en/content/articlelanding/2020/CS/D0CS00359J#!divAbstract
Abstract: Here, we report the application of surface-enhanced Raman scattering (SERS) spectroscopy as a rapid and practical tool for assessing the formation of coordinative adducts between nucleic acid guanines and ruthenium polypyridyl reagents. The technology provides a practical approach for the wash-free and quick identification of nucleic acid structures exhibiting sterically accessible guanines. This is demonstrated for the detection of a quadruplex-forming sequence present in the promoter region of the c-myc oncogene, which exhibits a non-paired, reactive guanine at a flanking position of the G-quartets.
External link: https://pubs.acs.org/doi/abs/10.1021/acs.jpclett.0c02148
In this manuscript, we present a nickel(II)‐mediated self‐assembly of a multimeric DNA binder composed of two metal‐chelating peptides derived from a bZIP transcription factor and one short AT‐hook domain equipped with two bipyridine ligands.
External link: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202001277
José Luis Mascareñas, PhD leads this team of researchers. Find out more about him and the rest of the team in our Group members section.
Group MembersWe are always looking forward to welcoming exceptional candidates into our research Group. Please visit our Opportunities section or send us your cv.
OpportunitiesAnnual mean temperature. The humid oceanic climate guarantees mild weather throughout the year.
Students attend the University. With the city population around 100,000.
Year old University. Currently imparting more than 60 degrees.
Santiago is well connected, having its own international airport, train station, etc.
Amongst many awards, Santiago was declared World Heritage City by UNESCO in 1985.
Santiago de Compostela is the capital of Galicia de most Nortwestern region of Spain.
Public transport is available in order to get around the city, which is also conveniently located to visit other sites in Galicia.
Spanish and Galician are the two official languages of Galicia. Your work will be carried out in English.
Official websites:
University of Santiago
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